Additional file 1 of Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study

Additional file 1: Fig. S1. Representative images of full-thickness porcine retinal sections after culture for 8 days with the different treatment conditions. Fig. S2. Rhodopsin distribution in porcine retinal explants is not altered by VCP inhibition. Fig. S3. VCP inhibition does not affect the survival of porcine cone photoreceptors. Fig. S4. Iba1 protein expression in porcine retinal explants. Fig. S5. Effect of VCP inhibition by free ML240 in macaque and human retinal explants. Fig. S6. Rod outer segments and rhodopsin localization are not altered by VCP inhibition in macaque and human retinal explants. Fig. S7. VCP inhibition does not affect macaque or human cone photoreceptor survival. Fig. S8. VCP inhibition by free ML240 does not affect other retinal cell types in macaque and human explants in vitro.