Additional file 1 of c-Rel drives pancreatic cancer metastasis through fibronectin-integrin signaling-induced isolation stress resistance and EMT

Supplementary Material 1.Supplementary Material 1. Supplementary Figure 1. A) Immunoblot analyses of c-Rel and β-actin expression in human and mouse cancer cells isolated from primary PDAC tumors that spontaneously formed in GEMMs. Each mouse line was isolated from an individual tumor. B) Representative IHC images indicating c-Rel expression in mouse PDAC primary (CKP n= 18, CK n=5, CKPhet n=9) and metastatic tumors (liver_met n= 4, lung_met n=3) and the histogram graph for the percentage of c-Rel expressing cancer cells. C) The given PDAC patient datasets were analyzed to determine the prognostic impact of REL expression on overall survival (OS). The table is generated with data from pdacR analysis. D) c-Rel H-scores are compared for patients stratified based on various clinical parameters. E) Representative images for c-Rel IHC in CCKP and GCKP tumors.