Additional file 5 of Advancing prion diagnostics: full-length human E200K RT-QuIC substrate facilitates prion detection in tear fluid and improves sensitivity in cerebrospinal fluid

Supplementary Figure 5: Impact of the PRNP codon 129 MV genotype in sCJD on the TF RT-QuIC signal response. A) Comparison of kinetic curves of positive TF RT-QuIC reactions of different PRNP codon 129 MV genotypes in sCJD (MM, MV, VV). B-C) Applying quantitative parameters, such as the area under the curve (AUC) and duration of the lag-phase we observed no significant differences in signal response in the TF RT-QuIC assay among different PRNP codon 129 MV genotypes (n = 4 per group)