Supplementary Material for: PATIENT-REPORTED OUTCOMES AFTER SURGERY FOR PROLIFERATIVE VITREORETINOPATHY: POST HOC ANALYSIS OF A RANDOMIZED CONTROLLED TRIAL

Introduction Proliferative vitreoretinopathy (PVR) is the leading cause of surgical failure in rhegmatogenous retinal detachment (RRD) and is associated with poor visual prognosis. We aimed to report changes in VFQ-25 and SF-36 tests following surgery for PVR-RRD and identify clinical and demographic factors associated with recovery. Methods This is a post-hoc analysis of a phase IIIb randomised, participant-masked clinical trial evaluating slow-release dexamethasone in PVR-RRD. Patients underwent pars plana vitrectomy with silicone oil tamponade. Vision-related QOL was assessed using VFQ-25, and SF-36 test, at baseline, 6 months, and 12 months postoperatively. VFQ-25 subscales and SF-36 domains were analysed descriptively and with non-parametric paired tests; associations with best-corrected visual acuity (BCVA, logMAR) and other variables were assessed using Spearman correlation and non-parametric tests. Results A total of 139 patients were included (mean age 61 years; 60% male). VFQ-25 total score improved from a median of 65.5 at baseline to 70 at 12 months (p=0.0004). SF-36 total score improved from 68 to 77.5 at 12 months (p=0.006). Worse 12-month BCVA correlated with lower VFQ-25 (p