Additional file 1 of LDOC1 connects histone H2B monoubiquitination to tumor cell plasticity in non-small cell lung cancer

Supplementary Material 1: Sequences and structural features of LDOC1. (A) Primary amino acid sequence of human LDOC1 (UniProt Q9BUV0), highlighting the leucine zipper domain (residues 11–43, yellow), proline-rich region (residues 61–70, blue), and a highly acidic C-terminal region (residues 115–145, purple). Leucine residues in the zipper motif are indicated in red. (B) Ribbon diagram of AlphaFold-predicted LDOC1 structure (AF-Q9BUV0-F1). (C) Electrostatic surface potential map of LDOC1 rendered in PyMOL using APBS. Red indicates negatively charged and blue indicates positively charged regions. The C-terminal region forms a prominent electronegative surface.