Additional file 1 of Mapping cellular vulnerability in Parkinson’s disease using retro-AAVs and preformed α-synuclein fibrils
Abstract
Additional file 1. Figure S1. PFF injection into the PPN region leads to p-αSYN pathology in cholinergic PPN neurons. Figure S2. AAV-retro-CRE based input tracing of PPN neurons. Figure S3. Output tracing of projection-based targeted BST, CEA, SNr, and DN neurons. Figure S4. Control qRT-PCR measurements of housekeeping genes in BST, CEA, SNr, and DN. Figure S5. Mitochondrial oxidative stress measurements of SNr neurons. Figure S6. Seeding deficiency of PFFs in noradrenergic LC neurons. Table S1. Coordinates of stereotactic surgery of respective brain regions. Table S2. Primary and secondary antibodies and the dilutions used in the study. Table S3. P values global pathology on contralateral hemisphere. Table S4. P values global pathology on ipsilateral hemisphere.
Fields of Study & Subjects
Parkinson's Disease Mechanisms and Treatments
Alzheimer's disease research and treatments
Neurological disorders and treatments
Publication details
- Journal / source
- Figshare
- Publication date
- 1 January 2026