Additional file 1 of Mapping cellular vulnerability in Parkinson’s disease using retro-AAVs and preformed α-synuclein fibrils

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Authors: Fanni F. Geibl, Ahmed A. S. Musa, Leo Dietrich, Helena Kern Wolter, David L. Wokosin, Sharof Khudayberdiev, Marco B. Rust, Rong Chen, Valina Lynn Dawson, Ted M. Dawson, Wolfgang Hermann Oertel, Dalton James Surmeier
+1 more Martin T. Henrich
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Abstract

Additional file 1. Figure S1. PFF injection into the PPN region leads to p-αSYN pathology in cholinergic PPN neurons. Figure S2. AAV-retro-CRE based input tracing of PPN neurons. Figure S3. Output tracing of projection-based targeted BST, CEA, SNr, and DN neurons. Figure S4. Control qRT-PCR measurements of housekeeping genes in BST, CEA, SNr, and DN. Figure S5. Mitochondrial oxidative stress measurements of SNr neurons. Figure S6. Seeding deficiency of PFFs in noradrenergic LC neurons. Table S1. Coordinates of stereotactic surgery of respective brain regions. Table S2. Primary and secondary antibodies and the dilutions used in the study. Table S3. P values global pathology on contralateral hemisphere. Table S4. P values global pathology on ipsilateral hemisphere.

Fields of Study & Subjects

Parkinson's Disease Mechanisms and Treatments Alzheimer's disease research and treatments Neurological disorders and treatments

Publication details

Journal / source
Figshare
Publication date
1 January 2026