Age-associated differences in XBB.1.5 trivalent booster vaccine-induced adaptive responses revealed by single-cell RNA sequencing

Figshare 2026 Dataset Open access

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Authors: Shixing Chen, Tao Liu, Chen, Jing, Shengxia Yin, Jinqiu Ran, Zhang, Wen, Wanying Zhang, Juan Zhang, Chen Li, Xun Wang, Pengfei Wang, Chao Wu
+2 more Fan Yang, Yuxin Chen
DOI: 10.6084/m9.figshare.31240998
Cited by: 0

Abstract

Older adults remain highly vulnerable to severe SARS-CoV-2 outcomes despite multiple vaccinations, yet age-associated differences in immune responses to updated COVID-19 booster vaccines remain incompletely characterized. Here, we administered an XBB.1.5 trivalent recombinant protein booster (WSK-V102C) to 22 individuals (

Fields of Study & Subjects

SARS-CoV-2 and COVID-19 Research Immune responses and vaccinations T-cell and B-cell Immunology

Publication details

Journal / source
Figshare
Publication date
1 January 2026
Document type
Dataset