Rapid Quality Screening of Intra-lot Variability of Acetazolamide Using Near-Infrared Spectrometry

PubMed 2026 Open access

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Authors: Uiyeol Yoon, Ayumi Tarianto, Philip J Almeter, Eleonora Hasani, Aaron N Hunter, Thomas A Lyman, Stephanie P Zapata, Bradley S Henderson, Seth A Larkin, Adler Crumrin, Jerod Smith, Spencer Pergrem
+12 more Ashton Plymale, Bailee Ramnes, Reagan Knight, Erin Vongchan, Samantha Schnabel, Bailey Hall, Kyra Sharp, Madison Geib, Abby Wingate, Alexander Bacanurschi, Ryan W. Naseman, Robert A. Lodder
DOI: 10.6084/m9.figshare.31242187
Cited by: 0

Abstract

and was positioned 4.03 standard deviations from the center of the lot cluster in multidimensional spectral hyperspace. These results suggest that the manufacturing process may have been operating outside of a state of process control. Given the ongoing national shortages of acetazolamide as of January 2026, such quality assurance screenings are critical for maintaining supply chain transparency and ensuring the reliability of medication used in evolving clinical protocols.

Fields of Study & Subjects

Spectroscopy and Chemometric Analyses Analytical Methods in Pharmaceuticals Pharmaceutical Quality and Counterfeiting

Publication details

Journal / source
PubMed
Volume
2026
Publication date
1 January 2026
Language
EN