Additional file 7 of Calcineurin depletion coincides with phosphorylated TDP-43 deposition in a mouse model of ALS/FTLD-TDP

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Authors: Sarah M. Waldherr, Randall J. Eck, Joshua C. Hincks, Heather N. Currey, Matvey Goldberg, Pamela J. McMillan, Aleen D. Saxton, Heino Hulsey-Vincent, Caitlin S. Latimer, Brian C. Kraemer, Nicole F. Liachko
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Abstract

Supplementary Material 7. Figure S7: Activation of calcineurin using an independent transgene protects against TDP-43 neurotoxicity in C. elegans. a A second transgene overexpressing wildtype TAX-6 in C. elegans (tax-6 o/ex 2) improves TDP-43 Tg motor dysfunction. Statistical analysis is by unpaired t-test, two-tailed (n ≥ 150; N = 3 independent experiments; *: p < 0.05).

Fields of Study & Subjects

Amyotrophic Lateral Sclerosis Research Alzheimer's disease research and treatments Muscle Physiology and Disorders

Publication details

Journal / source
Figshare
Publication date
1 January 2026