A single-cell and spatial transcriptomic dataset of the segment-specific intestinal responses to acute high-fat diet exposure

Figshare 2026 Dataset Open access

Read full text
Authors: Huanjie Yang, Zhiwen Cao, Li Pang, Qianqian Lyu, Zhensheng Dong, Wenzhi Xue, Juan Shen, Xiaodong Fang
DOI: 10.6084/m9.figshare.31293037
Cited by: 0

Abstract

This dataset provides a comprehensive spatiotemporal transcriptomic resource of the mouse intestine (Duodenum, Jejunum, Ileum, and Colon) in response to a short-term (1-day) high-fat diet (HFD) challenge. By integrating single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics, we characterize the rapid, segment-specific cellular and molecular adaptations of the intestinal epithelium and its microenvironment.

Fields of Study & Subjects

Single-cell and spatial transcriptomics Gut microbiota and health Diet Metabolism and Disease

Publication details

Journal / source
Figshare
Publication date
1 January 2026
Language
EN
Document type
Dataset