Additional file 1 of Impairment of oxidative metabolism compromises Rad51 recruitment and potentiates PARP inhibitor effectiveness in ovarian cancer

Supplementary Material 1: Formenti et al_Supplementary. Supplementary figures and legends. Supplementary Figure 1. PGC-1β silencing impairs TCA cycle activity without upregulating compensatory pathways. Supplementary Figure 2. PGC-1β silencing and IACS-010759 did not alter total Rad51 amount. Supplementary Figure 3. Post-translational modifications of Fen1. Supplementary Figure 4. IACS-010759 impairs the oxidative metabolism of ID8 cells. Supplementary Figure 5. IACS-010759 addition does not alter ID8 Brca2-/- cell intrinsic response to olaparib. Supplementary Figure 6. OXPHOS inhibition does not alter the sensitivity of human normal cells to olaparib. Supplementary Figure 7. Statistical analysis of in vivo experiments. Supplementary Figure 8. The treatments do not affect the body weight of OC-PDX-bearing mice. Supplementary Figure 9. PGC-1β silencing does not alter ATP level.