Additional file 2 of O-GlcNAcylation expression predicts a favorable prognosis and mitigates malignant phenotypes via MYCN suppression in neuroblastoma
Abstract
Supplementary Material 2. Supplementary Fig. 2: Quantitative analysis of immunohistochemical staining in Th-MYCN transgenic mice tumors.Quantification of (A) O-GlcNAc, (B) MYCN, and (C) GAP43 expression levels in tumor tissues from control and Thiamet G-treated Th-MYCN mice (corresponding to the representative images in Fig. 5E). Data are presented as the mean percentage of positive cells (or H-score) ± SD (n = 6 per group). Thiamet G treatment significantly increased O-GlcNAc and GAP43 levels while reducing MYCN expression compared to the control group. **p < 0.01 (Student’s t-test).
Fields of Study & Subjects
Neuroblastoma Research and Treatments
Glycosylation and Glycoproteins Research
Glioma Diagnosis and Treatment
Publication details
- Journal / source
- Figshare
- Publication date
- 1 January 2026
- Language
- EN