Additional file 3 of O-GlcNAcylation expression predicts a favorable prognosis and mitigates malignant phenotypes via MYCN suppression in neuroblastoma

Supplementary Material 3: Supplementary Fig. 3: Functional enrichment analysis of O-GlcNAc-regulated pathways in neuroblastoma. Pathway enrichment analysis of the global proteomic dataset from Thiamet G-treated TH-MYCN tumors compared to controls. The analysis reveals that Thiamet G-induced O-GlcNAc accumulation significantly impacts key metabolic pathways, including glycolysis, the pentose phosphate pathway (PPP), the tricarboxylic acid (TCA) cycle, and glutamine metabolism, as well as RNA processing.