Additional file 1 of Comparative risk of delirium among opioid users for non-cancer pain: a retrospective cohort study

Additional file 1: Supplementary Methods: Data preparation steps for processing and converting electronic administration data into daily opioid doses. Supplementary Table 1: ICD-10 codes for covariates used in the study. Supplementary Fig. 1: Directed Acyclic Graph demonstrating potential effect of confounders and effect modifiers. Supplementary Table 2: Baseline characteristics by opioid dosage at initiation. Supplementary Table 3. Main analysis—Comparative Risk of Delirium Associated with Different Opioids (morphine as reference). Supplementary Table 4. Association between administered opioid exposure & delirium (sensitivity analyses). Supplementary Table 5. Association between Morphine Milligram Equivalents per day thresholds & delirium (stratified analyses). Supplementary Results: Stratified analyses, including patients undergoing major or orthopaedic surgery, with and without serious infection during admission and BMI < 20. Supplementary Table 6. Association between administered opioid exposure & delirium (stratified analyses).