Additional file 1 of BRD4-mediated transcriptional activation of PDLIM4 enhances p21 stability and chemosensitivity in lung adenocarcinoma independent of p53

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Authors: Qingwei Wang, Liangsheng Guo, Shuai Wang, Chengdan Guan, Junhao Pan, Shaoping Zhu, Lei Zheng, Xuehua Wu, Yonghui Gu, Tao Shu, Lianxiang Luo, Tianwen Lai
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Abstract

Additional file 1: Figure S1. Stable overexpression or knockdown PDLIM4 cells were constructed. Figure S2. PDLIM4 inhibits proliferation and arrests cell cycle in LUAD cells. Figure S3. BRD4 controls the expression of PDLIM4. Figure S4. PDLIM4 co-localizes with p21 at various period during cell cycle. Figure S5. The regulation of the BRD4/PDLIM4/p21 axis in LUAD cells. Figure S6. BRD4-PDLIM4-p21 pathway sensitizes cells to chemotherapy. Figure S7. Rescue experiment. Table S1. All shRNA and primer sequences used in this paper. Table S2. Sequences of homo primers used for RT-PCR. Original Data.

Fields of Study & Subjects

Protein Degradation and Inhibitors Cancer-related Molecular Pathways Chromatin Remodeling and Cancer

Publication details

Journal / source
Figshare
Publication date
1 January 2026
Language
EN