Additional file 1 of BRD4-mediated transcriptional activation of PDLIM4 enhances p21 stability and chemosensitivity in lung adenocarcinoma independent of p53
Abstract
Additional file 1: Figure S1. Stable overexpression or knockdown PDLIM4 cells were constructed. Figure S2. PDLIM4 inhibits proliferation and arrests cell cycle in LUAD cells. Figure S3. BRD4 controls the expression of PDLIM4. Figure S4. PDLIM4 co-localizes with p21 at various period during cell cycle. Figure S5. The regulation of the BRD4/PDLIM4/p21 axis in LUAD cells. Figure S6. BRD4-PDLIM4-p21 pathway sensitizes cells to chemotherapy. Figure S7. Rescue experiment. Table S1. All shRNA and primer sequences used in this paper. Table S2. Sequences of homo primers used for RT-PCR. Original Data.
Fields of Study & Subjects
Protein Degradation and Inhibitors
Cancer-related Molecular Pathways
Chromatin Remodeling and Cancer
Publication details
- Journal / source
- Figshare
- Publication date
- 1 January 2026
- Language
- EN