Additional file 3 of Mitochondrial HMGCS1 mediates cisplatin resistance in cervical cancer through regulation of mitochondrial transcription

Supplementary Material 3: Supplementary Fig. S3. Cisplatin-resistant cells show increased binding of HMGCS1 and core transcription factors to the MtDNA D-loop. (A-D) Mitochondrial DNA immunoprecipitation (MtDIP) analysis showing the binding of HMGCS1 (A), mitochondrial RNA polymerase (POLRMT) (B), mitochondrial transcription factor A (TFAM) (C), and mitochondrial transcription factor B2 (TFB2M) (D) to different regions of mtDNA in parental and cisplatin-resistant (CisR) HeLa cells. The binding enrichment is presented as a percentage of input. Data are presented as mean ± SD. Statistical significance was determined using Student’s t-test: *p < 0.05, **p < 0.01, ***p < 0.001, ns: not significant