Additional file 4 of Reduced serum AHR agonistic activity reflects amyloid dysregulation in AT1 subtypes of Alzheimer’s disease

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Authors: Thanos Tsaktanis, Laura Rudtke, Leander Ammon, Stefan Mestermann, Veit Rothhammer, Piotr Lewczuk, Juan Manuel Maler, Johannes Kornhuber, Timo Jan Oberstein
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Abstract

Supplementary Material 4: Supplementary Figure 3. Baseline characteristics comparison between participants with and without available inflammation marker data Violin/box plots comparing key demographic, cognitive, and biomarker characteristics between participants with available inflammation markers (A, n = 86) and those without available data (N/A, n= 52). Jittered points represent individual participants; box plots display median and interquartile range. CSF Aβ1-40 z-scores were modestly but significantly lower in the inflammation subcohort (p = 0.01, d = -0.69). P-values derived from two-sided t-tests; Cohen's d represents standardized effect sizes. This analysis demonstrates that the inflammation subcohort is broadly representative of the full study sample, with only minor differences in CSF Aβ1-40 levels. *p < 0.05.

Fields of Study & Subjects

Alzheimer's disease research and treatments Dementia and Cognitive Impairment Research Neuroinflammation and Neurodegeneration Mechanisms

Publication details

Journal / source
Figshare
Publication date
1 January 2026
Language
EN