RAW DATD OF CCRL2 deficiency inhibits thermogenesis in mice by altering macrophage polarization
Abstract
The findings highlight CCRL2 as a critical regulator of macrophage polarization and its effects on thermogenic signaling in sWAT. The study identifies a unique non-adrenergic pathway involving p38 MAPK phosphorylation, which challenges conventional understanding of thermogenesis promotion. These insights offer potential therapeutic avenues for addressing obesity by targeting macrophage-mediated metabolic disruptions.
Fields of Study & Subjects
Adipose Tissue and Metabolism
Adipokines
Inflammation
and Metabolic Diseases
Peroxisome Proliferator-Activated Receptors
Publication details
- Journal / source
- Figshare
- Publication date
- 1 January 2026
- Language
- EN
- Document type
- Dataset