Comparative cost per responder analysis of Ciltacabtagene autoleucel and real-world standard of Care therapy in patients with lenalidomide-refractory multiple myeloma

Ciltacabtagene autoleucel (cilta-cel) is a chimeric antigen receptor T-cell therapy currently approved for relapsed/refractory multiple myeloma (RRMM). This study aimed to assess the value of cilta-cel against a real-world standard of care (RW-SoC) basket using a novel cost per responder (CPR) model. The model was aligned with the patient population in the CARTITUDE-4 trial and incorporated progression-free survival (PFS), post-progression survival (PPS), and death states. The base-case analysis was conducted from a mixed US payer perspective with a 36-month time horizon, and modeled outcomes included the total cost per treated patient, total cost per complete responder, and cost per month during PFS. In the base-case analysis, total cost per treated patient over 36 months was estimated to be lower for cilta-cel ($792,243) compared with RW-SoC ($815,023), with the difference driven predominantly by the lower costs for cilta-cel over the PPS period. Total costs per complete responder and per month during PFS were $1,070,599 and $25,203 for cilta-cel compared with $5,101,186 and $38,018, respectively, for RW-SoC. The CPR model suggests that cilta-cel offers substantial clinical and economic benefit for patients with RRMM compared with RW-SoC therapies. Ciltacabtagene autoleucel (cilta-cel) is a treatment for people with a type of blood cancer called multiple myeloma that has come back or those who did not respond to other treatments. This study looked at how cilta-cel compares to other commonly used treatments. It used efficacy and safety data from a clinical trial and costs from standard databases to estimate average total costs over three years in the United States. The analyses used a model to assess the average total cost for each patient treated, the average cost for each patient who had a complete response (meaning that the cancer was not detectable), and the average cost per month for each patient without disease progression. The results showed that the average total cost of cilta-cel for each patient treated over three years was lower compared to other treatments. This was mainly because cilta-cel was effective in delaying worsening of the condition and had lower costs after the disease progression. Also, the average costs for cilta-cel for each patient who had a complete response and the average monthly costs for each patient without disease progression were considerably lower compared to other treatments. In conclusion, the study suggests that cilta-cel provides health and cost benefits for patients with this type of blood cancer compared to other common treatments.