Spectral Intra-Lot and Inter-Lot Variability in Methacholine

PubMed 2026 Open access

Read full text
Authors: Uiyeol Yoon, Ayumi Tarianto, Philip J Almeter, Eleonora Hasani, Aaron N Hunter, Thomas A Lyman, Stephanie P Zapata, Bradley S Henderson, Seth A Larkin, Adler Crumrin, Jerod Smith, Spencer Pergrem
+12 more Ashton Plymale, Bailee Ramnes, Reagan Knight, Erin Vongchan, Samantha Schnabel, Bailey Hall, Kyra Sharp, Madison Geib, Abby Wingate, Alexander Bacanurschi, Robert A. Lodder, Ryan W. Naseman
DOI: 10.6084/m9.figshare.31413281
Cited by: 0

Abstract

=0.02. While these quantified deviations do not definitively prove the presence of adulteration or an excess level of impurities, they strongly indicate that the manufacturer's production pipeline may have drifted outside of a state of strict process control, warranting further investigation.

Fields of Study & Subjects

Analytical Methods in Pharmaceuticals Pharmaceutical Quality and Counterfeiting Spectroscopy and Chemometric Analyses

Publication details

Journal / source
PubMed
Volume
2026
Publication date
1 March 2026
Language
EN