Discovery of novel antibiotic thioether derivatives against tobacco bacterial wilt (Ralstonia solanacearum)

This study focuses on the synthesis of six novel thioether derivatives with potent antimicrobial activity against Ralstonia solanacearum, the causative agent of tobacco bacterial wilt. This disease, which has caused significant economic losses, has become increasingly resistant to traditional bactericides. In response, the study investigates the potential of thioether derivatives, known for their broad spectrum of biological activities, as eco-friendly alternatives. Through SEM observations, molecular docking, and DFT calculations, we identified DHFR as a potential target for these compounds, particularly highlighting compound R4, which showed superior activity compared to conventional controls. Additionally, toxicity predictions and ADME simulations suggest that compound R4 could be a promising, safe agricultural antimicrobial agent. This research aims to expand the range of agricultural chemical frameworks and contribute to the development of more effective and environmentally friendly solutions for pest and disease control.