Additional file 1 of Tetrahydropalmatine alleviates cancer induced bone pain by inhibiting TRPV1-SP-mediated macrophage recruitment and promoting M2 polarization

Supplementary Material 1.Figure 1 THP exhibits no effect on either bone mineral density or tumor size in CIBP mice a Representative microCT images of femurs from mice in the Sham, CIBP, and CIBP-THP (80 mg/kg) groups at day 14 post-modeling. Red arrows indicate bone destruction. b Quantitative analysis of Whole Mean bone mineral density (BMD) in femurs from each group at day 14. c Comparison of tumor weights between the CIBP and CIBP-THP groups after tumor extraction at day 21. NS indicates no statistically significant difference. Data were analyzed using one-way (b) ANOVA with Bonferroni’s post hoc test (> 2 groups) and unpaired t test (c); *p < 0.05, **p < 0.01, ***p < 0.001; error bar, SD