Additional file 5 of Cell-intrinsic vulnerability and immune activation cooperate to drive degeneration in a mitochondrial complex I deficiency model of optic neuropathy

Supplementary Material 5. Supplementary Fig S5. Myeloid cell depletion improves survival of peripheral RGCs in α-Cre; Ndufs4fl/fl retinas. A) Retinal flat-mounts stained with RBPMS (teal) show a partial rescue of RGCs in the periphery of α-Cre; Ndufs4fl/fl mice upon myeloid cell depletion with PLX5622 when compared to AIN76A control chow. B and C) Quantification of RBPMS+ RGCs per mm2 in animals fed with regular chow, AIN76A, or AIN76A supplemented with PLX5622. The central and peripheral retina were quantified separately (two-way ANOVA, n.s. not significant, **P < 0.01, ***P < 0.001, and ****P < 0.0001).