Sepsis-induced changes in membrane expression of GIRK1, GIRK4, CaV1.3, and HCN4 in murine sinoatrial node pacemaker cells.

Figshare 2026 Dataset Open access

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Authors: Niroj Shrestha, Klaus Zorn‐Pauly, Pietro Mesirca, Chintan N. Koyani, Valentina Di Biase, Gerald Wölkart, Eleonora Torre, Petra Lang, Astrid Gorischek, Wolfgang Schreibmayer, Robert Arnold, H. Maechler
+6 more Bernd Mayer, Dirk von Lewinski, Angelo Giovanni Torrente, Matteo Elia Mangoni, Brigitte Pelzmann, Susanne Scheruebel
DOI: 10.6084/m9.figshare.31665463
Cited by: 0

Abstract

Data sets include standardized immunofluorescence membrane levels of GIRK1, GIRK4, CaV1.3 and HCN4 in mock (CTRL) and Lipopolysaccharide (LPS) - treated sinoatrial pacemaker cells (SAN) isolated from mice. Intraperitoneal LPS injection was used to induce sepsis. After 6h, SAN cells were dissociated and plated onto poly-l-lysine-coated glass coverslips with 18-mm diameter at plating density of 25 to 30 cells/100 µL and processed for quantitative fluorescence immunolabelling.

Fields of Study & Subjects

Cardiac electrophysiology and arrhythmias Sepsis Diagnosis and Treatment Ion channel regulation and function

Publication details

Journal / source
Figshare
Publication date
12 March 2026
Language
EN
Document type
Dataset