Alzheimer’s disease on Sorokdo

Figshare 2026 Open access

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Authors: JONG HOON LEE
DOI: 10.6084/m9.figshare.31742815
Cited by: 0

Abstract

While the amyloid hypothesis has long dominated Alzheimer's disease (AD) research, the fundamental immunological "trigger" that converts transient inflammation into chronic neurodegeneration remains debated. In this study, we present a landmark discovery: a stepwise viral-immune cascade mediated by the SAMHD1-cGAS-STING axis, validated through a unique 17-year "natural experiment" in the Sorok Island cohort.

Fields of Study & Subjects

Alzheimer's disease research and treatments Neuroinflammation and Neurodegeneration Mechanisms interferon and immune responses

Publication details

Journal / source
Figshare
Publication date
15 March 2026
Language
EN