Early metabolic reprogramming and carbonic anhydrase IX-mediated extracellular acidification drive radiotherapy-induced glioblastoma cell dedifferentiation

Figshare 2026 Open access

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Authors: Perrine Dahan, T.M. Maillet, Laure Malric, Caroline Delmas, V. Lubrano, Judith Martinez-Gala, Guillaume Flandin, A. Aboudaram, Cécile Héliès‐Toussaint, Nicolas Skuli, Sylvie Monferran, Yvan Nicaise
+4 more Clémentine Decamps, Christine Toulas, Elizabeth Cohen-Jonathan Moyal, Anthony Lemarié
DOI: 10.6084/m9.figshare.c.8229118.v1
Cited by: 0

Abstract

Article highlights Mitochondrial metabolism is enhanced in GSC compared to their differentiated progeny. IR-induced dedifferentiation in GBM cells occurs via an early metabolic shift to OXPHOS. IR-induced metabolic shift links CA9 induction, extracellular acidification, and stemness.

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Figshare
Publication date
1 January 2026