Supplementary material from "Neoantigens and Stochastic Fluctuations Regulate T Cell Proliferation in Primary and Metastatic Malignant Brain Tumors"

Brain cancer can occur as primary or metastatic tumors. Sequencing of resected tissues from primary glioblastoma (GBM) and brain metastases (BrMET) reveals high heterogeneity in neoantigens and T cell receptor (TCR) repertoires. Analysis of published sequencing data from different spatial regions of tumors in GBM and BrMET patients reveals a heavy right-tailed distribution of T cell clone sizes, spanning several orders of magnitude (1–1000 cells), with a few large clone sizes (