Insights from Brazilian supercentenarians
Abstract
Supercentenarians provide a rare human model of exceptional longevity, marked by unique immune, genetic, and metabolic profiles that support resilience against age-related decline. Brazil's highly admixed population offers unparalleled opportunities to uncover protective mechanisms often missed in more homogeneous cohorts. Here, we describe ongoing genomic and cellular studies of a nationwide Brazilian cohort, featuring individuals who remained highly functional and survived COVID-19 unvaccinated. These individuals allow us to investigate molecular, immunological, and systemic pathways of resilience, offering insights that may inform strategies to extend health span.
Fields of Study & Subjects
Genetics
Aging
and Longevity in Model Organisms
Immune responses and vaccinations
GDF15 and Related Biomarkers
Publication details
- Journal / source
- Genomic psychiatry :
- Publisher
- Genomic Press
- Volume
- 2
- Issue
- 1
- Pages
- 18–20
- Publication date
- 6 January 2026