Inhomogeneous Branching Random Walks: Incorporating Genealogy and Density Effects

We introduce a novel framework using inhomogeneous branching random walks (BRWs) to model biological processes, specifically by introducing genealogy-dependence in branching rates and displacement distributions to model bacterial colony growth. Current stochastic models often either assume independent and identical behavior of individual agents or incorporate only spatiotemporal inhomogeneity, ignoring the effect of genealogy-based inhomogeneity on the long-time behavior of these processes. Such asymptotics are of independent mathematical interest and are crucial in understanding the emergence of patterns. We propose several inhomogeneous BRW models in 2D space where displacement distributions and branching rates vary with time, space, and genealogy. A combined model then uses a weighted average of positions given by these separate models to study the shape of the growth patterns. Using computer simulations, we tune parameters from these models, which are based on genealogical and spatiotemporal factors, observe the resulting structures, and compare them with images of real bacterial colonies.