Clozapine for elderly people with schizophrenia
Abstract
Clozapine is a potent antipsychotic mainly used in treatment-resistant schizophrenia. Its clinical efficacy in elderly patients is sparsely documented. Elderly patients achieve higher plasma levels of clozapine, requiring careful dose adjustments to minimize side effects such as sedation, hypotension, metabolic disorders, and notably pneumonia and ileus - both associated with significant mortality. Individualized dosing and regular monitoring are essential to ensure optimal safety and tolerability in elderly patients receiving clozapine, as argued in this review.
Fields of Study & Subjects
Schizophrenia research and treatment
Pharmaceutical studies and practices
Pharmaceutical Practices and Patient Outcomes
Publication details
- Journal / source
- Ugeskrift for Læger
- Volume
- 188
- Issue
- 3
- Pages
- 1–9
- Publication date
- 12 January 2026
- Language
- DA