Endogenous HMGB1 regulates GSDME-mediated pyroptosis via ROS/ERK1/2/caspase-3/GSDME signaling in neuroblastoma: Am J Cancer Res. 2023; 13(2): 436-451

American Journal of Cancer Research 2026 Open access

Read full text
Authors: Chen-Ying Fan, Fang-Hua Ye, Min Peng, Jiajia Dong, Wenwen Chai, Wenjun Deng, Hui Zhang, Liangchun Yang
DOI: 10.62347/bexd5889
Cited by: 18
References: 37

Abstract

, a ROS agonist) and EGF (an ERK agonist) promoted the cleavage of GSDME and caspase-3 in DDP or VP16 treatment cells, both of which were inhibited by HMGB1 knockdown. Importantly, these data were further supported by the in vivo experiment. Our study suggests that HMGB1 is a novel regulator of pyroptosis via the ROS/ERK1/2/caspase-3/GSDME pathway and a potential drug target for therapeutic interventions in neuroblastoma.

Fields of Study & Subjects

Heme Oxygenase-1 and Carbon Monoxide Neonatal Health and Biochemistry Inflammasome and immune disorders

Publication details

Journal / source
American Journal of Cancer Research
Publisher
e-Century Publishing Corporation
Volume
16
Issue
6
Pages
2671–2674
Publication date
1 January 2026
Language
EN