IL-23 promotes PD-L1 expression and tumor immune evasion via METTL16 pathway

American Journal of Cancer Research 2026 Open access

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Authors: Xueshan Pan, Yue Wang, Jingjing Luo, Xingna Dai, Jialin Zhang, Rui Zheng, Hui Xu, Yingjie Zhang, Jifeng Zhang, Zhiwei Wang, Tong Cao, Jia Ma
DOI: 10.62347/ddra7133
Cited by: 1

Abstract

T cell infiltration and IFN-γ secretion within the tumor microenvironment. Collectively, these findings establish the IL-23/METTL16/PD-L1 axis as a novel regulatory pathway and potential therapeutic target in cancer immunotherapy.

Fields of Study & Subjects

Cancer Immunotherapy and Biomarkers Psoriasis: Treatment and Pathogenesis NF-κB Signaling Pathways

Publication details

Journal / source
American Journal of Cancer Research
Publisher
e-Century Publishing Corporation
Volume
16
Issue
8
Pages
3678–3693
Publication date
1 January 2026
Language
EN