Cumulative triglyceride glucose waist-to-height ratio and hypertension risk in middle-aged and older Chinese adults

Objectives: The triglyceride-glucose waist-to-height ratio (TyG-WHtR) is a promising marker of insulin resistance and cardiometabolic risk.However, prospective evidence that links cumulative exposure to TyG-WHtR with incident hypertension is still limited, particularly among ageing populations.This study aimed to examine the prospective association between the cumulative average TyG-WHtR and the risk of developing hypertension in middleaged and older Chinese adults.Methods: Data relating to 5,803 adults aged ≥ 45 years from the China Health and Retirement Longitudinal Study (CHARLS) was analysed.TyG-WHtR was calculated at baseline (2011) and follow-up (2015) and the exposure variable was the cumulative average.Incident hypertension between 2015 and 2018 was ascertained.RCS (restricted cubic spline) and multivariable logistic regression modelling were utilised to examine the relationship between hypertension risk and cumulative average TyG-WHtR.ROC (receiver operating characteristic) curve analysis was used to further assess predictive accuracy.Results: Hypertension was developed in 1,685 participants (29.0%) over a median follow-up period of 36.5 months.A higher cumulative average TyG-WHtR was substantially linked to an elevated risk of hypertension in a dose-dependent way.People in the highest quartile were found to have markedly higher odds of hypertension (fully adjusted OR = 1.73, 95% CI: 1.17-2.55,P = 0.006) than those in the lowest quartile.A positive linear correlation was validated using RCS analysis (P-overall = 0.007).The ROC curve showed there to be good predictive accuracy and the fully adjusted model yielded an AUC of 0.962 (95% CI: 0.955-0.969).Conclusion: The cumulative average TyG-WHtR is independently linked to incident hypertension in elderly and middle-aged Chinese people.This index could be an economical and accessible means for early risk assessment and prevention in community and clinical settings.