PRMT5 inhibits the ferroptosis of hepatocellular carcinoma via regulating RBM15/FTH1 signaling
Abstract
. Moreover, PRMT5 could interact with RNA binding motif protein 15 (RBM15) to activate ferritinophagy signaling. RBM15-mediated m6A modification of ferritin heavy chain 1 (FTH1), promoting its mRNA expression and stability. However, overexpression of FTH1 suppressed ferroptosis and promoted tumor growth. Taken together, PRMT5/RBM15/ferritinophagy signaling can be a potential target for HCC.
Fields of Study & Subjects
Cancer-related gene regulation
Ferroptosis and cancer prognosis
RNA modifications and cancer
Publication details
- Journal / source
- American Journal of Cancer Research
- Publisher
- e-Century Publishing Corporation
- Volume
- 16
- Issue
- 1
- Pages
- 125–140
- Publication date
- 1 January 2026
- Language
- EN