Analysis of food-specific IgE, IgG, and IgG4 antibodies in children with allergic diseases
Abstract
OBJECTIVE: To assess the clinical value of food-specific IgE (sIgE), IgG (sIgG), and IgG4 (sIgG4) in the diagnostic evaluation of allergic diseases in children. METHODS: A total of 149 pediatric patients with allergic diseases were retrospectively enrolled and categorized into three groups based on their predominant clinical manifestations: digestive symptoms, skin symptoms, and respiratory symptoms. Ninety-six age-matched healthy children were included as the control group. Serum total IgE and food-specific sIgE, sIgG, and sIgG4 levels were measured simultaneously. RESULTS: The overall positivity rates of food-specific sIgG and sIgG4 in the case group were significantly higher than those of sIgE (P
Fields of Study & Subjects
Food Allergy and Anaphylaxis Research
Allergic Rhinitis and Sensitization
Eosinophilic Esophagitis
Publication details
- Journal / source
- American Journal of Translational Research
- Volume
- 18
- Issue
- 1
- Pages
- 605–617
- Publication date
- 1 January 2026
- Language
- EN