Effects of semiconductor laser combined with compound chlorhexidine- and dexamethasone membrane therapy on periodontal health and gingival crevicular fluid inflammation in patients with chronic periodontal disease

OBJECTIVE: To explore the effects of a semiconductor laser combined with compound chlorhexidine and dexamethasone membrane in the treatment of chronic periodontal disease, and its effects on periodontal health and gingival crevicular fluid inflammatory factors. METHODS: The clinical data of 100 patients with chronic periodontal disease were retrospectively analyzed. According to different treatment methods, they were divided into a conventional treatment group (n=46, receiving conventional periodontal basic treatment) and a combined treatment group (n=54, receiving conventional treatment plus semiconductor laser and compound chlorhexidine-dexamethasone membrane). Periodontal health-related indicators, gingival crevicular fluid inflammatory factor levels, and Oral Health Impact Profile-14 (OHIP-14) scores were compared before and after treatment. The clinical efficacy and occurrence of adverse reactions were evaluated. RESULTS: After treatment, the plaque index, probing depth, sulcus bleeding index, attachment loss, interleukin-6, high-sensitivity C-reactive protein and tumor necrosis factor-αlevels were lower than before treatment, and the OHIP-14 scores were improved (all P