Predictive value of the combined application of oxidative stress indicators and carcinoembryonic antigen for patients with early lung adenocarcinoma

OBJECTIVES: To explore the expression levels of oxidative stress indicators and carcinoembryonic antigen (CEA) in different pathologic types of pulmonary ground-glass nodules (GGN) and their predictive value for early lung adenocarcinoma. METHODS: This study was a retrospective analysis. General data were collected from 100 patients diagnosed in The Affiliated Taizhou People's Hospital of Nanjing Medical University from February 2022 to May 2024 with GGN in the lungs. According to pathologic types, they were divided into the glandular prodromal lesion group (n=39) and the lung adenocarcinoma group (n=61). The pretreatment levels of CEA, reactive oxygen species (ROS), superoxide dismutase (SOD), and malondialdehyde (MDA) were compared between the two groups. Risk factors for developing early-stage lung adenocarcinoma were screened by univariate versus multivariate logistic regression analysis. The receiver operator characteristic curve (ROC) was used to evaluate the predictive value of each index for early lung adenocarcinoma. RESULTS: Compared to the glandular prodromal lesion group, the levels of ROS, MDA and CEA in the lung adenocarcinoma group were significantly higher, while the level of SOD was significantly lower (P