Testosterone Therapy in diabetic and non-diabetic patients with Chronic Kidney Disease: growing interest and potentially new therapeutic implications

This is a short editorial summarizing a highly relevant clinical problem from an epidemiological perspective i.e. the possible pathophysiological links between testosterone deficiency (hypogonadism) in males, a condition known as hypogonadism, and renal function in patients with chronic kidney disease. While these two conditions may share important pathophysiological links, in clinical practice they are mostly considered unrelated. Testosterone hormone replacement therapy (HT) may likely help reduce the progression of chronic kidney disease, although patient phenotyping and the recognition of potential diagnostic biases must be considered to avoid risks.