THE CONTROL OF SOME HORMONES RELATING TO CUTANEOUS AGING: MECHANISMS, MANIFESTATIONS, AND MANAGEMENT

To summarize current evidence on the interaction between endocrine factors and skin aging, with a focus on the role of hormones and endocrine pathways. This review was conducted through a literature search in PubMed using the keywords “hormone,” “skin aging,” and “cutaneous aging.” Studies addressing the role of hormones in age-related changes of skin physiology were reviewed and synthesized. Skin aging is closely associated with hormonal changes. In women, the sharp decline in estrogen during menopause is a central factor driving aging, leading to reduced collagen and elastin synthesis, dermal thinning, loss of hydration, and increased sensitivity to environmental stressors. In men, the gradual decrease in testosterone also contributes to skin aging, though typically less prominently. Overall, the evidence highlights hormones as key regulators of skin health and resilience. The changes of some hormones play an important role in the process of skin aging. These findings underscore the potential of future skin rejuvenation strategies targeting endocrine pathways.