Tridax procumbens Leaf Extract Mitigated Vincristine-Induced Organ Pathology and Oxidative Imbalances in Wistar Rats

Objective: This study investigated the effect of Tridax procumbens (TP), a medicinal plant, on Vincristine sulphate (VC)-induced oxidant-antioxidant imbalances in the liver and pancreas of male Wistar rats. Methods: Thirty rats (80-100 g) were randomly allocated into six groups (Groups 1–6) and treated as follows: Group 1 (control) received 1 mL/kg body weight distilled water orally (p.o.), Group 2 received 0.1 mg/kg body weight VC intraperitoneally (i.p.), Groups 3 and 4 received 50 and 100 mg/kg body weight TP extract orally (p.o.), respectively. Group 5 received VC (0.1 mg/kg body weight, i.p.) plus TP (50 mg/kg body weight, p.o.) while Group 6 received VC (0.1 mg/kg body weight, i.p.) plus TP (100 mg/kg body weight, p.o.). The rats were treated for 10 consecutive days. Oxidant-antioxidant biomarkers and histology of the liver and pancreas of the rats were assessed. Results: Vincristine sulphate reduced the activities of Glutathione S-Transferase (GST), Glutathione Peroxidase (GPx) (p