Biologic Innovations in Orthopedics: A Comprehensive Review of Orthobiologic Therapies for Joint Preservation and Tissue Regeneration

Orthobiologics are an innovative area of development in musculoskeletal medicine that provides regenerative options as substitutes for conventional orthopedic procedures aimed at preserving joints and healing soft tissues. The purpose of this review was to critically assess orthobiologic therapy effectiveness, describe novel developments, and provide clinical and investigative recommendations. A systematic search of scholarly databases was conducted, targeting studies published from 2018 to 2025. 11 peer-reviewed articles were included and analyzed through thematic synthesis. Findings indicated that PRP, BMAC, and MSCs provide clinically relevant benefits of pain, function, and tissue repair in osteoarthritis and tendinopathy. Orthobiologics, exosome therapies, scaffold-enhanced delivery systems, and gene-activated matrices are newer innovations that are continuing to expand the clinical use of orthobiologics.