Endocrine Regulation in Aging: Hormonal Decline, Compensatory Mechanisms, and Prospects for Healthy Aging Interventions

This study examines the processes, physiological outcomes, and novel interventions of endocrine aging through a systematic evidence-based analysis methodology. Peer-reviewed research published between 2020 and 2025 provided data collected on the basis of competitive endocrine achievements, hormonal disorderliness, and multi-organizational biological outcomes analyzed using predetermined inclusion criteria. The research also examines the modern and developing treatment methods, such as hormone modulation, lifestyle change, pharmacological agents, and precision endocrinology. The study suggest that endocrine aging is a consequence of progressive dysfunction in the production of hormones, the sensitivity of receptors, and cross-axis feedback regulation, which causes metabolic dysfunction, immune dysfunction, neurocognitive dysfunction, and frailty. New hormonal-based interventions show promise to enhance endocrine resistance and healthy lifespan. The paper identifies some major gaps in research in the areas of biomarker development, integration of multi-omics, artificial intelligence, and ethical aspects of hormone-based longevity treatment.