Addiction Psychopharmacology in Patients with Medical Comorbidities

Apply evidence-based dosing adjustments for naltrexone, buprenorphine, methadone, and disulfiram in patients with hepatic impairment, renal insufficiency, cardiovascular disease, and respiratory conditions. Identify which medications for alcohol use disorder and opioid use disorder are safe, require dose modification, or should be avoided across specific comorbid conditions, including decompensated cirrhosis and severe renal disease. Describe integrated care models for managing patients with co-occurring substance use disorders and medical comorbidities, including liver disease and infectious conditions.