FACTORS OF DEVELOPMENT AND LAWS OF THE COURSE OF DUODENAL ULCER DISEASE IN CONDITIONS OF ARTERIAL HYPERTENSION

The importance of the comorbid course of diseases currently remains indisputable for the scientific and practical activities of every doctor. Arterial hypertension is one of the urgent problems not only in Uzbekistan, but also around the world. Duodenal ulcer disease (DUD) also occupies a leading position among diseases of the gastrointestinal tract. The comorbid course of hypertension and DUD represents a fundamentally new position of the regulatory systems of the body, since the etiology, pathogenesis, and pathomorphology of both nosologies reveal common mechanisms of development. The multifactorial nature of both pathologies has similarities at the level of neurohumoral and hormonal regulation, imbalance of the sympathetic and parasympathetic nervous systems, and changes in the microcirculatory system. It was revealed that there is a connection between erosive and ulcerative lesions of the gastroduodenal zone and the degree of hypertension. This review will consider the general etiological and pathomorphological mechanisms of development in the case of hypertension and DUD.