Community and academic hospitals participating in a randomized trial: Patient characteristics, research capacity and trial metrics

ABSTRACT Introduction Patient populations in Canadian community and academic hospitals may differ with respect to demographic and clinical characteristics, as well as outcomes. Community hospitals may also differ with respect to research capacity and trial performance. The objectives of this study are to examine differences between community and academic hospitals participating in the REVISE trial with respect to: 1) patient characteristics; 2) research capacity, and 3) trial metrics. Methods and analysis This is a preplanned secondary analysis of the REVISE trial (Re-Evaluating the Inhibition of Stress Erosions), which enrolled patients in 42 ICUs in Canada. Baseline demographic and descriptive outcomes for community and academic hospital patients will be reported using descriptive statistics and compared using t-tests, Wilcoxon rank-sum tests or Chi 2 test, as appropriate, with p