Effects of the GABA B receptor agonist 3-aminopropyl (methyl) phosphinic acid on food intake in free feeding rats

Abstract The GABA B agonist baclofen has been shown to increase food intake in rats by a GABA B receptor mediated mechanism. The present study, was undertaken to extend these observations by investigating the effects of intraperitoneal (ip) administration of the potent GABA B receptor agonist 3-aminopropyl (methyl)phosphinic acid (SKF97541) on food intake in free feeding rats. In the first experiment, male Wistar rats (n=6) received intraperitoneal (ip) injections of saline or SKF97541 (0.1, 0.2, or 0.4 mg / kg), with food intake monitored over 120 minutes. The results showed that the 0.1 and 0.2 mg/kg doses of SKF97541 significantly increased cumulative food intake at 120 min (at least P