Nephron-associated Support Cell Transcriptional Plasticity Expands in Hypertension

Hypertension (HTN) affects over one billion people worldwide and can lead to debilitating cardiovascular and renal conditions if left untreated. Cell death in the kidneys and the inflammation that follows are among the primary effects of chronically elevated blood pressure. There are several cell types throughout the body with immunomodulatory, anti-inflammatory, and pro-regenerative properties that support tissue homeostasis and recent studies have highlighted their therapeutic potential in HTN and kidney-related conditions. In our previous paper, we found a pool of multipotent nephron-associated support cells (SCs) in single-cell RNA sequencing samples of CD31+ and podoplanin+ cells taken from the kidneys of hypertensive mice generated through two mouse models of HTN. Despite remaining roughly constant in number between HTN and control groups, these SCs had 299 differentially expressed genes (p