CHANGES IN INCIDENCE AND SEROTYPE DISTRIBUTION OF PEDIAT-RIC INVASIVE PNEUMOCOCCAL DISEASE AFTER THE INTRODUCTION OF 15-VALENT PNEUMOCOCCAL CONJUGATE VACCINE IN CATALONIA, SPAIN. A MULTICENTER SURVEILLANCE STUDY

medRxiv 2026 Preprint Open access

Read full text
Authors: Carmen Muñoz‐Almagro, Maria Cisneros, Claudia Alcaraz, Sonia Broner, F.A. Moraga Llop, A Rosell, Alvaro Díaz‐Conradi, Pedro Brotons, Desirée Henares, Gerard González-Comino, Belén Viñado, Fréderic Gómez-Bertomeu
+23 more Clara Marco, Sebastià González‐Peris, Jaume Llaberia, Conchita Izquierdo, Jessica Galvez, Amaresh Pérez-Argüello, Rosauro Varo, Jordi Iglesies-Torrent, Cristina Esteva, Mayuli Armas, Miguel Blanco-Fuertes, Núria Torrellas-Bertran, Maria Mar Olga Perez, I. Valle, Marian Navarro, Alba Rivera, Montserrat Colomer, Laura Solaz, Miquel Micó, Juan José García‐García, Ángela Domı́nguez, Mariona Fernández de Sevilla, Pilar Ciruela
DOI: 10.64898/2026.02.11.26346066
Cited by: 0
References: 29

Abstract

ABSTRACT Background Serotype 3 (S3) has remained a major cause of invasive pneumococcal disease (IPD) despite its inclusion in 13-valent pneumococcal conjugate vaccine (PCV). In October 2023, a 15-valent PCV (PCV15) including S3 was introduced into the Catalan universal childhood immunization program. Methods We conducted a retrospective pre-post surveillance study to compare pediatric IPD incidence in Catalonia during a pre-PCV15 period (October 1, 2022-September 30, 2023) and two post-PCV15 periods (October 1, 2023-September 30, 2024, and October 1, 2024-September 30, 2025). All IPD episodes in children

Fields of Study & Subjects

Pneumonia and Respiratory Infections Bacterial Infections and Vaccines Microbial infections and disease research

Publication details

Journal / source
medRxiv
Publication date
12 February 2026
Language
EN
Document type
Preprint