Transcriptomic data of larval zebrafish exposed to continuous sub- and supra-MCL sodium arsenite and uranyl nitrate.
Abstract
Uranium (U) and arsenic (As) are both ubiquitous contaminants in the American southwest, posing risks to humans, animals, and the environment. Depleted uranium's (DU) chronic effects and mechanisms of toxicity are incompletely understood. Differential gene expression of concomitant exposures to identify markers of toxicity have not been undertaken until now. Continuous low-dose, high-dose, and concomitant exposures are investigated using the larval zebrafish (Danio rerio), with exposure paradigms lasting from embryo collection until sampling at 5 days post fertilization (dpf). Herein, we describe overall differential gene expression with counts and pathway enrichment statistics using both gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. The raw dataset has been deposited in NCBI's Gene Expression Omnibus (GEO) repository [1] under the accession number GSE319292 [2].
Fields of Study & Subjects
Environmental Toxicology and Ecotoxicology
Morphological variations and asymmetry
Heavy Metal Exposure and Toxicity
Publication details
- Journal / source
- bioRxiv (Cold Spring Harbor Laboratory)
- Publisher
- openRxiv
- Publication date
- 23 February 2026
- Language
- EN
- Document type
- Preprint