Leisure-time physical activity on lifelong trajectories of body mass index and obesity risk throughout life: multivariable regression and Mendelian randomization analyses using real-world data from the CORDELIA-Catalunya Study

medRxiv 2026 Preprint Open access

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Authors: Javier Hernando Redondo, Anna Camps-Vilaró, Roberto Elosúa, Eleonora Fornara, Marcelino Bermúdez-López, Pere Torán-Monserrat, Ainara Jimenez-Navarro, José Manuel Valdivielso, Victor M. López-Lifante, Tomás Salas, Serafi Cambray, Raquel Cruz
+2 more Jaume Marrugat, Álvaro Hernáez
DOI: 10.64898/2026.02.23.26346892
Cited by: 1
References: 41

Abstract

ABSTRACT Background Evidence on how leisure-time physical activity (LTPA) improves lifetime body mass index (BMI) remains fragmented and prone to confounding. Methods We pooled 14,993 adults (30-90 y; 52.7% women; cohorts: REGICOR-ACRISC, ILERVAS, ARTPER) with baseline estimated LTPA (moderate-to-vigorous LTPA [MVLTPA] in REGICOR-ACRISC), genotype, and repeated BMI values from electronic health records (1990-2024, 36,157 measures). LTPA was categorized into cohort-specific quartiles; MVLTPA in 0,

Fields of Study & Subjects

Genetic Associations and Epidemiology Genetics and Physical Performance Physical Activity and Health

Publication details

Journal / source
medRxiv
Publisher
openRxiv
Publication date
25 February 2026
Document type
Preprint